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N,N-Dimethylformamide N,N-二甲基甲酰胺

规格: 99%, SpcDry, with molecular sieves, Water≤50 ppm (by K.F.), SpcSeal

CAS: 68-12-2

产品编号: H79932

MDL: MFCD00003284

品牌: INFI

Chemical Name	N,N-Dimethylformamide
Synonym	N,N-Dimethylformamide {LY} N,N-Dimethylformamide N,N-dimethylformamide N,N-二甲基甲酰胺 N,N-二甲基甲酰胺, ANHYDROUS, 99.8%, PACKAGED UNDER ARGON I N,N-二甲基甲酰胺, HPLC GRADE, 99.7+%, PACKAGED UNDER ARGON N-甲酰二甲胺 NCI-C60913 NSC 5356 N，N-二甲基甲酰胺 amide,n,n-dimethyl-formicaci dimethylformamide (DMF) {} {LY} N,N-Dimethylformamide {} {} {LY} N,N-Dimethylformamide {} {} {} {LY} N,N-Dimethylformamide {} {} {} {} {LY} N,N-Dimethylformamide {} {} {} {} {} { {} {} {} {} {} {LY} N,N-Dimethylformamide {} {} {} {} {} {} {LY} N,N-Dimethylformamide {} {} {} {} {} {} {} {LY} N,N-Dimethylformamide {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} N,N-Dimethylformamide {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} N,N-Dimethylformamide {} {} {} {} {} {} {} {} {} {} {LY} N,N-Dimethylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	68-12-2
PubChem Substance ID	6228
EC Number	200-679-5
Beilstein Registry Number	605365
MDL Number	MFCD00003284
Reaxys-RN	605365
Merck Number	3243
Chemical Name Translation	N,N-二甲基甲酰胺
Wiswesser Line Notation	VHN1&1
LabNetwork Molecule ID	LN00163315
InChI	InChI=1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3
Canonical SMILES	CN(C=O)C

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Liver - other changes
   Kidney, Ureter, Bladder - other changes in urine composition
   Blood - changes in cell count (unspecified)
REFERENCE :
   BJIMAG British Journal of Industrial Medicine.  (British Medical Journal,
   Box 560B, Kennebunkport, ME 04046)  V.1-    1944-  Volume(issue)/page/year:
   13,51,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 470 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 15,618,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3700 mg/kg
TOXIC EFFECTS :
   Behavioral - somnol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNCRA6 Cancer Chemotherapy Reports.  (Bethesda, MD)  V.1-52, 1959-68.  For
   publisher information, see CTRRDO.  Volume(issue)/page/year: 30,9,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1050 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Human
DOSE/DURATION           : 12300 ug/m3/Y
REFERENCE :
   ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete.  (VEB
   Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
   Rep.)  V.1-    1955-  Volume(issue)/page/year: 31,366,1985

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 300 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,502,1981

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,468,1981

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 ug/kg/24H
REFERENCE :
   DOYADI Dongwuxue Yanjiu.  Zoological Research.  (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China)  V.1-    1980-
   Volume(issue)/page/year: 8,27,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 600 ug/plate
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,343,1981

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   DEGEA3 Deutsche Gesundheitswesen.  (VEB Verlag Volk und Gesundheit, Neue
   Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-
   Volume(issue)/page/year: 30,455,1975

{h

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5030 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 5200 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:

WGK Germany	1
Hazard Codes	3 T
Hazard statements
H312+H332 H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害 H319 Causes serious eye irritation 严重刺激眼睛 H226 Flammable liquid and vapour 易燃液体和蒸气
Personal Protective Equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECS	LQ2100000
Precautionary statements
P201 Obtain special instructions before use. 使用前获取专门指示。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P301+P312+P330 P303+P361+P353 P305+P351+P338 P305+P351+P338+P310 P308+P313 P403+P233 P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word	Danger
Safety Statements
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）； S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害 R36 Irritating to eyes 刺激眼睛 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
UN Number	2265 UN2265
Storage condition	2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
Packing Group	III
Hazard Class	3
Warnings	危化品目录(2015)
Restrict	危险品

许多疏水化合物的溶剂。非水溶液滴定用试剂，乙烯树脂和乙炔的溶剂，有机合成，光度测定，气相色谱固定液（最高使用温度50℃，溶剂为甲醇），分离分析C2-C5烃，并能分离正、异丁烯-[1]及顺、反丁烯-[2]。农药残留量分析。有机合成。肽的合成。照相工业用。

{ALF} In combination with POCl3, (COCl)2, etc., generates an iminium chloride intermediate for the formylation of reactive aromatic nuclei by the Vilsmeier reaction:

{ALF} CAUTION! Thermal runaway reactions can occur with NaH; see Sodium hydride, 13431.

{ALF} In aqueous DMF, tosylate esters undergo formolysis to formate esters: Synth. Commun., 26, 1031 (1996).

{ALF} Vilsmeier conditions also promote dehydrations, e.g. in cyclodehydration of hydroxyphenols to give cyclic ethers, as an efficient alternative to the Mitsunobu reaction: J. Chem. Soc., Perkin 1, 2249 (1996); J. Org. Chem., 59, 4346 (1994):

{ALF} Dipolar aprotic solvent, in which anions have enhanced nucleophilicity, compare Dimethyl sulfoxide, A13280. Effective solvent for a vast range of reactions.

{ALD} Merck: 14,3243

Beilstein: 4,IV,171

{ALF} Compare also N-Methylformanilide, A11829, and preformed Vilsmeier reagent (Chloromethylene)dimethylammonium chloride, B24172. Monograph: Synthesis Using Vilsmeier Reagents, C. M. Marson, P. R. Giles, CRC Press, Boca Raton, FL (1994). Formylation can be extended to less active substrates, e.g. acenaphthene or mesitylene, with the DMF-triflic anhydride reagent: J. Chem. Soc., Chem. Commun., 1571 (1990). Under Vilsmeier conditions, electron-rich alkenes can be converted to ɑß-unsaturated aldehydes; see, e.g.: Synthesis, 752 (1976); and ketones to ß-chloroenals: Synthesis, 496 (1985); Org. Synth. Coll., 5, 215 (1973).

{ALF} For the free-radical formylation of perfluoroalkyl iodides, see Zinc-copper couple, L09811.

{ALF} Vilsmeier conditi

{ALD} Merck: 14,3243

{ALF} DMF can also be used for formylation with alkyllithium or Grignard reagents: Synthesis, 228 (1984).

{ALFA} Vilsmeier conditions also promote dehydrations, e.g. in cyclodehydration of hydroxyphenols to give cyclic ethers, as an efficient alternati

68-12-2 H79932 N,N-Dimethylformamide
N,N-二甲基甲酰胺

化学属性

Mol. Formula	C3H7NO
Mol. Weight	73.09
Refractive index	1.4280 to 1.4320
Boiling Point	153
Density	0.924
Melting Point	-61
Flash Point	57.78°C
TSCA	Yes
Autoignition Point	833 °F
Vapor Density	2.5 (vs air)
Vapor Pressure	2.7 mmHg ( 20 °C)
Solubility	可溶
Stability	对湿度敏感
Danger-Level	乙类

*以上化合物性质及应用等信息仅供参考

电子化学品

催化剂

配体

有机硅

元素分类

其他精细新材料

N,N-Dimethylformamide N,N-二甲基甲酰胺

规格: 99%, SpcDry, with molecular sieves, Water≤50 ppm (by K.F.), SpcSeal

化学属性

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