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N,O-Bis(trimethylsilyl)acetamide N,O-双(三甲基硅烷基)乙酰胺

规格: 95%

CAS: 10416-59-8

产品编号: H67855

MDL: MFCD00008270

品牌: INFI

Chemical Name	N,O-Bis(trimethylsilyl)acetamide
CAS Number	10416-59-8
Alfabeta Name	BISTRIMETHYLSILYLACETAMIDE NO()-,
MDL Number	MFCD00008270
Synonym	BSA N,O-双(三甲基甲硅烷基)乙酰胺 Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester BSA HMDS TMCS in pyridine TMCS pyridine Trimethylsilyl N-trimethylsilylacetamidate; BSA; Dynasylan BSA Bis(trimethylsilyl)acetamide (BSA)/trimethylchlorosilane (TMCS) Bis(trimethylsilyl)acetamide HMDS N,O-Bis(trimethylsilyl)acetamide - Trimethylchlorosilane Mixture pentafluorobenzoyl chloride N,O-双(三甲基硅烷基)乙酰胺 N-(Trimethylsilyl)acetimidic acid, trimethylsilyl ester N,O-双三甲硅基乙酰胺
Reaxys-RN	2206090
PubChem Substance ID	87576562
EC Number	233-892-7
Beilstein Registry Number	1306669
Chemical Name Translation	N,O-双(三甲基甲硅烷基)乙酰胺
Wiswesser Line Notation	1-SI-1&1&OY1&UN-SI-1&1&1
LabNetwork Molecule ID	LN01745639

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg/I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   54,495,1975

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Immunological Including Allergic - decreased immune response
REFERENCE :
   StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine,
   School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 
   Volume(issue)/page/year: 27MAY1975

Warnings	IRRITANT
Hazard statements
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气 H226 Flammable liquid and vapour 易燃液体和蒸气 H302 Harmful if swallowed 吞食有害 H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
WGK Germany	3
Precautionary statements
P201 Obtain special instructions before use. 使用前获取专门指示。 P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。 P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P233 Keep container tightly closed. ?保持容器密闭。 P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。 P241+P242+P243 P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P301+P312+P330 P301+P330+P331+P310 P302+P352+P312+P361+P364 P303+P361+P353 P303+P361+P353+P310+P363 P304+P340+P310 P305+P351+P338 P305+P351+P338+P310 P305+P351+P338+P337+P313 P308+P311 P308+P313 P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。 P332+P313 P337+P313 P403+P235 P405 Store locked up. 上锁保管。 P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard Codes	8 C
Signal word	Danger
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US)
RTECS	AK3000000
UN Number	1992 2920
Storage condition	0-10 0-10°C Moisture Sensitive
Risk Statements
R10 Flammable 易燃 R11 Highly flammable 非常易燃 R14 Reacts violently with water 遇水会猛烈反应 R22 Harmful if swallowed 吞咽有害 R34 Causes burns 会导致灼伤 R35 Causes severe burns 会导致严重灼伤 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S30 Never add water to this product 切勿将水加入该产品中； S36 Wear suitable protective clothing 穿戴适当的防护服； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护； S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用（指明具体的消防器材种类，如果用水增加危险，注明“禁止用水” S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）； S7/8 Keep container tightly closed and dry 保存在严格密闭容器中，保持干燥；
Packing Group	II
Hazard Class	3/6.1

中性硅烷化保护剂，BSA产品是重要的医药中间体，主要用于合成孢头抗生素的生产。

{ALF} O-Silylation in the presence of TBAF (0.02 equiv.) occurs under very mild conditions: Tetrahedron Lett., 35, 8409 (1994).

{ALF} BSA catalyzes the acylation of acylphosphoranes with activated derivatives of carboxylic acids. Subsequent ozonolysis, or oxidation with singlet oxygen or dimethyldioxirane, provides a route to 1,2,3-triketones: J. Org. Chem., 54, 2785 (1989); 60, 8231 (1995):

{SNA}

{ALF} Powerful silylation reagent for a wide range of functional groups under mild conditions. See Appendix 4. Reviews: J. Prakt. Chem./ Chem. Ztg., 337, 332 (1995); Synthesis, 357 (1998). Unlike halosilanes, silylated amides often need no added base catalysts. For an example of use without added solvent or catalyst for the silylation of a tertiary ɑ-hydroxy ketone, see: Org. Synth. Coll., 7, 381 (1990). Silylating power can be increased in polar solvents such as DMF or acetonitrile, or by addition of acidic catalysts, often TMS chloride, or an acid such as TFA or HCl.

10416-59-8 H67855 N,O-Bis(trimethylsilyl)acetamide
N,O-双(三甲基硅烷基)乙酰胺

化学属性

Mol. Formula	C8H21NOSi2
Mol. Weight	203
Refractive index	1.4140 to 1.4180
Density	0.812
Flash Point	53 °F
TSCA	Yes
Boiling Point	71-73 °C 35 mm Hg(lit.)
Melting Point	21 - 27 °C
Stability	对湿度敏感

*以上化合物性质及应用等信息仅供参考

电子化学品

催化剂

配体

有机硅

元素分类

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N,O-Bis(trimethylsilyl)acetamide N,O-双(三甲基硅烷基)乙酰胺

规格: 95%

化学属性

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