DoMole-安徽敦茂科技

Cisplatin 顺铂

规格: 99%,Pt 64.5%

CAS: 15663-27-1

产品编号: H53754

MDL: MFCD00011623

品牌: INFI

Chemical Name	cis-Diammineplatinum(II) dichloride
Synonym	Platinum, diamminedichloro-, (SP-4-1)- trans-Dichlorodiammine platinum Dichlorodiammineplatinum(II)Transplatin Peyrone's chloride Platidiam cis-Dichlorodiammine platinum(II) Cisplatin cis-DDP Platinum, diamminedichloro-, trans- Cisplatyl Dichlorodiammineplati trans-Dichlorodiammineplatinum(II) cis-Platinum(II) diamminedichloride Transplatin 顺氯氨铂顺-二氯二氨基铂(II) trans-Dichlorodiamineplatinum(II) trans-DDP Diamminedichloroplatinum cis-Platinous diammine dichloride 顺-二氯二氨基铂(II) 顺式-二胺二氯铂顺氯氨铂 trans-Dichlorodiammineplatinum(II) 反式-二氨基二氯化铂(II) cis-Platin 顺式-二胺二氯铂
MDL Number	MFCD00011623
PubChem Substance ID	24871609
EC Number	239-733-8
CAS Number	15663-27-1
Merck Number	2317
Chemical Name Translation	顺式-二氯二氨基铂
InChIKey	DQLATGHUWYMOKM-UHFFFAOYSA-L
Wiswesser Line Notation	Z&2 PT-G2
LabNetwork Molecule ID	LN01250618

GHS Symbol

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32408 ug/kg/10W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,4368,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16 mg/kg/19W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,913,1979

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16204 ug/kg/10W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,4368,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7500 ug/kg
                          female 17 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17900 ug/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - hypermotility, diarrhea
   Blood - normocytic anemia
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 10,723,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IOBPD3 International Journal of Radiation Oncology, Biology, Physics.
   (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-
      1975-  Volume(issue)/page/year: 5,1417,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9200 ug/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - hypermotility, diarrhea
   Blood - normocytic anemia
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/ye

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10900 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTKRDX Gan to Kagaku Ryoho.  Cancer and Chemotherapy.  (1-8-9 Yaesu,
   Chuo-ku, Tokyo 103, Japan) V.1-

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 127,23,1984

TYPE OF TEST            : Micronucleu

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 125 ng/plate
REFERENCE :
   NULSAK Nucleus (Calcutta).  (Dr. A.K. Sharma, Centre of Advanced Studies in
   Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta
   700 019, India)  V.1-    1958-  Volume(issue)/page/year: 28,159,1985

{haz

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Neurospora crassa
DOSE/DURATION           : 200 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 125,43,1984

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 250 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   29,327,1980

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 4 mg/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:

TYPE OF TEST            : Specific locus test
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Else

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/p

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1100 ug/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   42,122,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V

WGK Germany	3
Precautionary statements
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P332+P313 P501 Dispose of contents/container to..… 处理内容物/容器..... P337+P313 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P201 Obtain special instructions before use. 使用前获取专门指示。 P308+P313 P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。 P305+P351+P338 P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。 P301+P310 P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。 P301+P312+ P305+P351+P338+P337+P313 P308+P311 P342+P311 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P301+P310+P330
Signal word
Hazard statements
H350 May cause cancer 可能致癌 H318 Causes serious eye damage 严重伤害眼睛 H300 Fatal if swallowed 吞食致命 H317 May cause an allergic skin reaction 可能导致皮肤过敏 H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难 H302 Harmful if swallowed 吞食有害 H319 Causes serious eye irritation 严重刺激眼睛
RTECS	TP2450000
Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）； S39 Wear eye/face protection 戴眼睛/面孔保护装置； S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明； S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套； S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾； S24 Avoid contact with skin 避免皮肤接触； S22 Do not breathe dust 不要吸入粉尘；
Packing Group	II
UN Number	UN3288
Risk Statements
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R42/43 R25 Toxic if swallowed 吞咽有毒 R45 May cause cancer 可能致癌 R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Hazard Codes	T Xn
Hazard Class	6.1

{uni_hamburg} Short: III/20b

Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei Cl ... Rb

Author: Chihara, H.; Nakamura, N.

Editor: Hellwege, K.-H.; Hellwege, A.M.

Source: Landolt-Börnstein, New Series

Volume: III/20b

Year: 1988

Keyword: NQR

ISBN: 3-540-18483-X

ISBN: 978-3-540-18483-6

Internet Resource: DOI:10.1007/b86664

RefComment: IX,717 pages. Hardcover

Abstract: Nuclear Quadrupole Resonance Spectroscopy has become a standard method for structural research in molecular and solid state physics as well as for different branches of chemistry. The volumes cover data for more than 8,000 substances in the solid state. Data for free molecules have been published in volumes II/14 and II/15 of the New Series. The tables are arranged according to the atomic number of the elements.

{uni_hamburg} Short: EINECS

Title: EINECS (European Inventory of Existing Commercial Chemical Substances)

Source: Official Journal of the European Communities

Volume: C 146 A (15.06.1990)

Page: 1

Year: 1990

Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein

Publish_Date: 1990/06/15

化学属性

Mol. Formula	cis-Pt(NH3)2Cl2
Mol. Weight	300
Melting Point	270
Solubility	Soluble in DMF. Insoluble in most common solvents
TSCA	No
Density	1.0

*以上化合物性质及应用等信息仅供参考

电子化学品

催化剂

配体

有机硅

元素分类

其他精细新材料

Cisplatin 顺铂

规格: 99%,Pt 64.5%

化学属性

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