DoMole-安徽敦茂科技

Hexamethyldisilazane 六甲基二硅氮烷

规格: 99%

CAS: 999-97-3

产品编号: H53534

MDL: MFCD00008259

品牌: INFI

Chemical Name	Bis(trimethylsilyl)amine
Synonym	(dimethyl-trimethylsilylamino-silyl)methane 1,1,1,3,3,3-Hexamithyl disilazane 1,1,1-trimethyl-n-(trimethylsilyl)-silanamin 1,1,1-三甲基-N-(三甲基甲硅烷基)硅烷胺 BSTFA Bis(trimethylsilyl)amine Bis-(trimethylsilyl)-amin Dow Corning® 产品 Z-6079 HMDS HEXAMETHYLDISILYLAMINE Hexamethyldisilazane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	999-97-3
PubChem Substance ID	13838
EC Number	213-668-5
Beilstein Registry Number	635752
MDL Number	MFCD00008259
Reaxys-RN	635752
Merck Number	4689
Chemical Name Translation	六甲基二硅氮烷
Wiswesser Line Notation	1-SI-1&1&M-SI-1&1&1
LabNetwork Molecule ID	LN00195588
InChI	InChI=1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg/I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   54,495,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0537734

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 850 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 30(5),52,1986

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Immunological Including Allergic - decreased immune response
REFERENCE :
   StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine,
   School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 
   Volume(issue)/page/year: 27MAY1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1 mL/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   F

WGK Germany	2
Hazard statements
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气 H302 Harmful if swallowed 吞食有害 H302+H332 H311 Toxic in contact with skin 皮肤接触中毒 H312 Harmful in contact with skin 皮肤接触有害 H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤 H315 Causes skin irritation 会刺激皮肤 H318 Causes serious eye damage 严重伤害眼睛 H319 Causes serious eye irritation 严重刺激眼睛 H332 Harmful if inhaled 吸入有害 H335 May cause respiratory irritation 可能导致呼吸道刺激 H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕 H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Personal Protective Equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes	3 F,C
RTECS	JM9230000
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P233 Keep container tightly closed. ?保持容器密闭。 P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。 P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。 P241+P242+P243 P242 Use only non-sparking tools. 只能使用无火花工具。 P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。 P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P264+P265 P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P273 Avoid release to the environment. 避免释放到环境中。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P301+P312 P301+P317 P301+P330+P331 P301+P330+P331+P310 P302+P352 P302+P361+P354 P303+P361+P353 P303+P361+P353+P310+P363 P304+P312 P304+P340 P304+P340+P310 P305+P351+P338 P305+P351+P338+P310 P305+P354+P338 P307+P311 P308+P311 P308+P316 P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。 P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。 P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。 P316 P317 P319 P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。 P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。 P330 Rinse mouth. 漱口 P332+P317 P337+P313 P337+P317 P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。 P361+P364 P362+P364 P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。 P370+P378 P403+P233 P403+P235 P405 Store locked up. 上锁保管。 P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word	Danger
UN Number	3286
Risk Statements
R11 Highly flammable 非常易燃 R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害 R34 Causes burns 会导致灼伤 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R52/53
Safety Statements
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟； S20 When using do not eat or drink 使用时，不得进食，饮水； S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S33 Take precautionary measures against static discharges 对静电采取预防措施； S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护； S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）； S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置； S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书； S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
Storage condition	+20°C 2-8°C 20 Moisture Sensitive 密封保存易潮解,密封保存
Packing Group	II
Hazard Class	3/6.1, 8
Warnings	危化品目录(2015)
Restrict	危险品

碱性硅烷化保护剂，无机填料处理剂

{uni_hamburg} Short: II/25D

{ALF} Can also function as a protected form of ammonia, e.g. to convert acid chlorides to primary amides: Synthesis, 517 (1985), and substituted maleic anhydrides to maleimides: Tetrahedron Lett., 31, 5201 (1990).

{ALF} For conversion of carbonyl groups to silyl enol ethers, see Iodotrimethylsilane, A12902.

{ALF} Convenient, mild silylating reagent which generates gaseous ammonia as the only by-product (see Appendix 4). Non-acidic substrates normally require a catalyst.

{ALF} A range of catalysts for silylation with HMDS, including saccharin and sodium saccharin, has been recommended: J. Org. Chem., 47, 3966 (1982), for silylation of alcohols, phenols, thiols, carboxylic acids, amides, thioamides, hydroxamic acids, hydrazides, NH-groups of heterocycles, hydrazines, 1,3-diketones, etc. The use of TBAF (0.02 eq.) or iodine (0.01 eq.) also provide mild procedures for O-silylation: Tetrahedron Lett., 35, 8409 (1994); J. Org. Chem., 65, 7228 (2000).

{ALD} Merck: 14,4689

Beilstein: 4,IV,4014

{uni_hamburg} Short: III/35B

{ALF} Silylation of alcohols, including carbohydrates, is catalyzed by TMS chloride: J. Org. Chem., 23, 50 (1958); J. Am. Chem. Soc., 85, 2497 (1963); Chem. Ind. (London), 794 (1984). Silylation of phenols occurs readily, see also: Liebigs Ann. Chem., 20 (1973).

{ALF} The Na, Li and K derivatives are useful strong bases; see Sodium bis(trimethylsilyl)amide, L13352, Lithium bis(trimethylsilyl)amide, L15012, and Potassium bis(trimethylsilyl)amide, L15022.

{ALF} HMDS in the presence of TMS chloride permits the selective O-silylation of amino alcohols: Synthesis, 990 (1988). Alcohols and phenols can be silylated in the presence of amines and thiols with ZnCl2 as catalyst: Synth. Commun., 23, 1633 (1993).

{ALF} In combination with DMSO, thiols are oxidized to disulfides under nearly neutral conditions: Synlett, 346 (2002).

{ALD} Merck: 14,4689

999-97-3 H53534 Hexamethyldisilazane
六甲基二硅氮烷

化学属性

Mol. Formula	C6H19NSi2
Mol. Weight	161
Refractive index	1.4060 to 1.4100
Boiling Point	125 °C(lit.)
Density	0.774
Flash Point	57.2 °F
TSCA	Yes
Melting Point	-81 - -75 °C
Solubility	起反应
Stability	易吸潮
pH	:A

*以上化合物性质及应用等信息仅供参考

电子化学品

催化剂

配体

有机硅

元素分类

其他精细新材料

Hexamethyldisilazane 六甲基二硅氮烷

规格: 99%

化学属性

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