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Hydroxytrimethylstannane 三甲基氢氧化锡

规格: 98%

CAS: 56-24-6

产品编号: H15248

MDL: MFCD00013929

品牌: INFI

一种温和的选择性水解试剂

酯类化合物的水解在有机合成中至关重要，但常用的水解方法存在以下问题：1）其他酯基同时水解；2）化合物的立体中心消旋化；3）发生不必要的消除反应。而三甲基氢氧化锡(Me3SnOH)作为一种温和的碱，可以实现化合物中酯基的选择性水解。

该方法首次发现是Scripps研究所K. C. Nicolaou课题组在研究硫链蛋白(一种高度复杂的硫肽抗生素)过程中，中间体敏感不能耐受普通水解条件，而Me3SnOH以高产率实现了乙酸甲酯和异丙酯的选择性水解[1]。自此他们课题组对Me3SnOH在酯水解应用中进行了深入的研究，实验结果表明，Me3SnOH在温和的进行酯基水解的同时，保护了在碱性条件下易消旋化的立体中心(如图一)；除此之外底物存在甲酯、乙酯和异丙酯等多种酯基时，可以实现选择性优先水解甲酯(如图二)。

图一：(R)-4-羟基苯甘氨酸衍生物的甲酯水解

图二：选择性酯水解

以上图片均来自参考文献

研峰科技拥有完整配套的研发生产设备，通过前期大量的工艺研究、公司规范有效的管控流程及智能管理系统，实现了三甲基氢氧化锡稳定量产，质量稳定，满足客户要求，还可以根据客户的需要进行定制。详细产品情况请致电客服人员（400-106-2016）进行咨询。

参考文献：Nicolaou, K.C., Estrada, A.A., Zak, M., Lee, S.H. and Safina, B.S. A Mild and Selective Method for the Hydrolysis of Esters with Trimethyltin Hydroxide. Angewandte Chemie International Edition, 2005, 44, 1378-1382.

Chemical Name	Trimethyltinhydroxide
Synonym	Hydroxytrimethylstannane Trimethylstannanol Stannane, hydroxytrimethyl- Trimethyl tin hydroxide Tin, hydroxytrimethyl- Trimethylstannyl hydroxide 三甲基氢氧化锡, 98% Hydroxytrimethyltin; Trimethylhydroxytin; Trimethylstannanol; Trimethylstannyl hydroxide Trimethyltin hydroxide Trimethylstannylhydroxid Trimethylzinnhydroxid Trimethylzinn-hydroxid Tin, trimethyl-, hydroxide Trimethylhydroxytin Hydroxytrimethyltin
MDL Number	MFCD00013929
CAS Number	56-24-6
Chemical Name Translation	三甲基氢氧化锡
Wiswesser Line Notation	Q-SN-1&1&1
LabNetwork Molecule ID	LN01301690

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1800 ug/kg
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 28,367,1926

RTECS	WH8400000
Safety Statements
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置； S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）； S27/28
Packing Group	II
UN Number	UN3146
Risk Statements
R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒 R50/53
Storage condition	Moisture Sensitive
Restrict	剧毒

{uni_hamburg} Short: III/5a

Title: Structure Data of Organic Crystals: C ... C 13

Author: Schudt, E.; Weitz, G.

Editor: Hellwege, K.-H.; Hellwege, A.M.

Source: Landolt-Börnstein, New Series

Volume: III/5a

Year: 1971

ISBN: 3-540-05177-5

ISBN: 978-3-540-05177-0

Internet Resource: DOI:10.1007/b19970

RefComment: XXI, 736 pages, and VII, 890 pages. Hardcover

Abstract: Volume III/5 offers a compitation as complete as possible of the space groups and lattice con-stants of all crystals which have been studied by means of X-rays, neutron and electron diffraction.

56-24-6 H15248 Hydroxytrimethylstannane
三甲基氢氧化锡

化学属性

Mol. Formula	(CH3)3SnOH
Mol. Weight	181
Melting Point	114-118°
TSCA	No
Flash Point	26 ºC
Boiling Point	119 ºC
Density	1.0

*以上化合物性质及应用等信息仅供参考

电子化学品

催化剂

配体

有机硅

元素分类

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Hydroxytrimethylstannane 三甲基氢氧化锡

规格: 98%

一种温和的选择性水解试剂

化学属性

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